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Genetic relatedness of the gene which codes for the nonstructural (NS) protein of different influenza a strains

Identifieur interne : 002810 ( Main/Exploration ); précédent : 002809; suivant : 002811

Genetic relatedness of the gene which codes for the nonstructural (NS) protein of different influenza a strains

Auteurs : C. Scholtissek [Allemagne] ; V. Von Hoyningen-Huene [Allemagne]

Source :

RBID : ISTEX:6BAC8422300A28703DB96A39BEF3B9A74DF31456

English descriptors

Abstract

Abstract: According to the base sequence homology of the gene coding for the nonstructural (NS) protein the influenza A viruses can be divided into at least three groups. Within each group the homology is about 90% or higher. The avian influenza A viruses fall at least into two groups between which the homology is about 40%. All human strains tested belong to another group. Influenza viruses of other species might comprise their own group(s). The related regions of the NS gene among the two groups of avian influenza viruses overlap completely and they are highly conserved. The results are discussed in terms of a selection pressure concerning the function exerted by the host during the evolution of the different NS genes, which also might explain a certain species specificity concerning the NS gene of influenza A viruses.

Url:
DOI: 10.1016/0042-6822(80)90065-3


Affiliations:


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<div type="abstract" xml:lang="en">Abstract: According to the base sequence homology of the gene coding for the nonstructural (NS) protein the influenza A viruses can be divided into at least three groups. Within each group the homology is about 90% or higher. The avian influenza A viruses fall at least into two groups between which the homology is about 40%. All human strains tested belong to another group. Influenza viruses of other species might comprise their own group(s). The related regions of the NS gene among the two groups of avian influenza viruses overlap completely and they are highly conserved. The results are discussed in terms of a selection pressure concerning the function exerted by the host during the evolution of the different NS genes, which also might explain a certain species specificity concerning the NS gene of influenza A viruses.</div>
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