Genetic relatedness of the gene which codes for the nonstructural (NS) protein of different influenza a strains
Identifieur interne : 002810 ( Main/Exploration ); précédent : 002809; suivant : 002811Genetic relatedness of the gene which codes for the nonstructural (NS) protein of different influenza a strains
Auteurs : C. Scholtissek [Allemagne] ; V. Von Hoyningen-Huene [Allemagne]Source :
- Virology [ 0042-6822 ] ; 1980.
English descriptors
- Teeft :
- Avian, Avian influenza, Avian influenza strains, Base sequence homology, Chick victoria, Crna, Experimental conditions, Fowl plague virus, Gene, Gene coding, Genes coding, Havlnl, Heterologous, Homology, Hswlnl, Human influenza, Human strains, Hybridization, Hybridized, Influenza, Influenza strains, Influenza viruses, Input radioactivity, Nonstructural, Nonstructural protein, Other influenza, Other species, Rnase, Rnase protection, Rohde, Scholtissek, Selection pressure, Strains table, Surface glycoproteins, Swine virus, Virology, Virus.
Abstract
Abstract: According to the base sequence homology of the gene coding for the nonstructural (NS) protein the influenza A viruses can be divided into at least three groups. Within each group the homology is about 90% or higher. The avian influenza A viruses fall at least into two groups between which the homology is about 40%. All human strains tested belong to another group. Influenza viruses of other species might comprise their own group(s). The related regions of the NS gene among the two groups of avian influenza viruses overlap completely and they are highly conserved. The results are discussed in terms of a selection pressure concerning the function exerted by the host during the evolution of the different NS genes, which also might explain a certain species specificity concerning the NS gene of influenza A viruses.
Url:
DOI: 10.1016/0042-6822(80)90065-3
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Abstract: According to the base sequence homology of the gene coding for the nonstructural (NS) protein the influenza A viruses can be divided into at least three groups. Within each group the homology is about 90% or higher. The avian influenza A viruses fall at least into two groups between which the homology is about 40%. All human strains tested belong to another group. Influenza viruses of other species might comprise their own group(s). The related regions of the NS gene among the two groups of avian influenza viruses overlap completely and they are highly conserved. The results are discussed in terms of a selection pressure concerning the function exerted by the host during the evolution of the different NS genes, which also might explain a certain species specificity concerning the NS gene of influenza A viruses.</div>
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